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How nurses care for central lines and keep TPN safe

5 min lesson 2 min for the key points

Fact-checked October 15, 2026

NCLEX-RN topic: Central venous access devices

In 30 seconds
  • Infection and air entry are the big dangers of a central line.
  • Scrub the hub at least 15 seconds and let it dry.
  • Flush with a 10-mL or larger syringe; never force against resistance.
  • Ask every day whether the line is still needed.
  • For TPN, check glucose, watch for fever, finish each bag within 24 hours.

Key facts

  1. CLABSI is a bloodstream infection in a client whose central line has been in place for more than 2 calendar days, with no other source.
  2. Change gauze dressings every 2 days and transparent dressings at least every 7 days, and right away if damp, loose or soiled.
  3. Scrub the needleless connector for at least 15 seconds and let it dry; use a 10-mL or larger syringe and never flush against resistance.
Show all 7 key factsShow fewer
  1. When fluoroscopy is not used during insertion, a chest X-ray confirms tip placement and checks for pneumothorax before the line is used.
  2. Solutions of 900 mOsm/L or more, including most TPN, must go through a central catheter, with a 0.22-micron filter (1.2 micron if lipid is included).
  3. TPN can cause hyperglycemia and infection; monitor glucose, report fever or chills, and complete each bag within 24 hours.
  4. A PICC arm that grows 3 cm or more in circumference may have a deep vein thrombosis.

Quick check1 question · 2 more at the end

A client's central venous catheter was placed 9 days ago for IV antibiotics. The last dose was given yesterday, and no further IV therapy is planned. Which action by the nurse best reduces the client's risk of a central line-associated bloodstream infection (CLABSI)?

Full lesson

Each part starts with its main idea. Open a part when you want the details.

The short answer: A central line carries fluids into a large vein near the heart, so infection and air entry are the big dangers. Scrub hubs, keep dressings dry and intact, flush with a 10-mL syringe, and ask daily whether the line is still needed. For TPN, check glucose, watch for fever and finish each bag within 24 hours.

1 What is a central line, and why does it need extra care?A central venous access device (CVAD) ends in a large vein near the heart, so anything entering it reaches the bloodstream at once. 1 min

A central venous access device (CVAD) ends in a large vein near the heart, so anything entering it reaches the bloodstream at once. It is used for concentrated solutions such as TPN, vesicant drugs and long-term therapy.

Device Typical use and duration
PICC (arm vein) Weeks up to about 6 months; avoid in end-stage kidney disease to save veins
Nontunneled (subclavian, jugular, femoral) Days to weeks; subclavian preferred in adults
Tunneled (chest) Long-term therapy such as chemotherapy
Implanted port Long-term; accessed with a noncoring needle

Before a new line is used, tip placement is confirmed per policy. Without fluoroscopy, a chest X-ray confirms the tip and looks for a pneumothorax.

2 How do you prevent a central line infection?Most CLABSI prevention is simple habits done every time. 1 min

Most CLABSI prevention is simple habits done every time. Warning signs are fever and red, sore skin around the line.

  • Hand hygiene before and after touching or dressing the line.
  • Chlorhexidine scrubbed back and forth for 30 seconds and allowed to dry; nurse and client both wear masks for a dressing change.
  • Gauze dressing every 2 days, transparent dressing at least every 7 days, and immediately if damp, loose or soiled; label it with date, time and initials.
  • Scrub the hub or needleless connector at least 15 seconds before every access.
  • Keep the site out of water.
  • Review every day whether the line is still needed and ask for prompt removal when it is not; lines are not replaced on a schedule.
3 How do you flush a line and draw blood safely?Gentle technique protects the catheter from rupture and the client from clots. 1 min

Gentle technique protects the catheter from rupture and the client from clots. Use a 10-mL or larger syringe, check for a blood return, and flush with 0.9% sodium chloride before and after infusions and blood draws. Never force against resistance; check for kinks and reposition the client first.

For a blood sample, pause the infusions, scrub, flush, and discard the first diluted blood (or use push-pull). Use a large lumen and flush 10 to 20 mL of saline afterward.

4 Which central line problems need action right now?A few complications are emergencies, and each has its own first move. 1 min

A few complications are emergencies, and each has its own first move.

Problem Clues First action
Air embolism Sudden dyspnea, coughing, chest pain; open hub Clamp, left side head down, high-flow oxygen
Pneumothorax After insertion: sharp chest pain worse on inspiration, dyspnea Stay, call for help, high-flow oxygen
Complete dislodgement Catheter out, site bleeding Cover the site, apply direct pressure, call the rapid response team
Broken catheter Leak or hole Clamp near the insertion site, cover with sterile gauze
Migration or DVT Longer external length; PICC arm 3 cm or more larger Notify the provider; never readvance
5 What changes when the line carries TPN?TPN is concentrated dextrose and amino acids, so glucose and infection are the main worries. 1 min

TPN is concentrated dextrose and amino acids, so glucose and infection are the main worries. Solutions of 900 mOsm/L or more go only through a central catheter, with the in-line filter the product requires.

  • Check glucose as prescribed; dextrose given faster than it can be used causes hyperglycemia, and insulin may be adjusted.
  • Keep the prescribed rate, and complete each bag within 24 hours.
  • Fever, chills, a high WBC count or a red, draining site suggest infection.
  • Precipitates can form; if breathing trouble develops, stop the infusion and get a medical evaluation.
6 What the nurse doesAssess the line every shift, act on emergencies at once, and teach the client how to protect it. 1 min

Assess the line every shift, act on emergencies at once, and teach the client how to protect it.

  1. Assess: site, dressing date, external length, PICC arm circumference, blood return, glucose and temperature.
  2. Act: use the first actions in the table, report fever or high glucose, and advocate for removal of unneeded lines.
  3. Teach: avoid touching the tubing and site, keep the dressing dry, and report fever, redness or new pain.

Common mistakes

The traps students fall into most. Read these before you practice.

  • Watch out: Remove a central line that is no longer needed, not keep it in reserve or replace it on a schedule.

  • Watch out: For pneumothorax, give high-flow oxygen and get help, not the left-side, head-down position used for air embolism.

  • Watch out: Stop TPN when the client develops respiratory distress and the tubing shows particles, not flush or slow it.

  • Watch out: Draw blood from a large lumen after pausing the infusions, not through a small lumen.

  • Watch out: Report a central catheter that has migrated out, not push it back in.

How to remember it

Remember "scrub, date, ask" as the three-word habit for every central line. Scrub the hub, date the dressing, ask daily if it is still needed.

Self-check:

  1. Name the dressing change intervals for gauze and transparent dressings.
  2. Tell pneumothorax apart from air embolism by cause and first action.
  3. List three TPN findings you would report.
Check yourself

Try it: 2 questions

  • 2 questions
  • Pharmacology
  • 5 min in exam mode

Questions are original practice items written to the published exam content, not real exam questions.

Finished this lesson? It is marked done when you finish the questions above. You can also mark it yourself.
Sources (6)
  1. Open RN Nursing Advanced Skills, 4.2 Basic Concepts (central venous access devices)
  2. Open RN Nursing Advanced Skills, 4.3 Applying the Nursing Process (central venous access devices)
  3. CDC: Summary of Recommendations, Guidelines for the Prevention of Intravascular Catheter-Related Infections
  4. CDC: About Central Line-associated Bloodstream Infections (CLABSI)
  5. DailyMed: Clinimix E (amino acids with electrolytes in dextrose with calcium) injection label
  6. MedlinePlus: Total parenteral nutrition

Written with AI and checked against the sources above by a separate review step. No RN reviews this content. How we make our content. For exam study only, not medical advice; follow your facility's policies and current guidelines in practice. HealthcareExams is independent and not affiliated with NCSBN.

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